1964: Week 12
20 games. One ranked team lost, to an unranked team. Winners are listed first; numbers before names are AP ranks going in.
The week in review
Upsets
A ranked team beaten as the betting favorite, or, where no line is on file, by an unranked or lower-ranked team.
FBS vs. FBS
| Nov 26, 1964 | 2Alabama 21, Auburn 14 | Box score |
| Nov 26, 1964 | Colorado State 35, UTEP 8 | Box score |
| Nov 26, 1964 | 5Texas 26, Texas A&M 7 | Box score |
| Nov 26, 1964 | Tulsa 21, Wichita State 7 | Box score |
| Nov 26, 1964 | Virginia Tech 35, VMI 13 | Box score |
| Nov 26, 1964 | William & Mary 33, Richmond 13 | Box score |
| Nov 28, 1964 | Arizona 30, Arizona State 6 | Box score |
| Nov 28, 1964 | Army 11, Navy 8 | Box score |
| Nov 28, 1964 | Baylor 27, Rice 20 | Box score |
| Nov 28, 1964 | Boston College 10, Holy Cross 8 | Box score |
| Nov 28, 1964 | Cincinnati 20, Houston 6 | Box score |
| Nov 28, 1964 | Florida 12, Miami 10 | Box score |
| Nov 28, 1964 | Georgia 7, Georgia Tech 0 | Box score |
| Nov 28, 1964 | New Mexico 9, Kansas State 7 | Box score |
| Nov 28, 1964 | Oklahoma 21, Oklahoma State 16 | Box score |
| Nov 28, 1964 | USC 20, 1Notre Dame 17upset | Box score |
| Nov 28, 1964 | TCU 17, SMU 6 | Box score |
| Nov 28, 1964 | Tulane 17, Duke 0 | Box score |
| Nov 28, 1964 | Vanderbilt 7, Tennessee 0 | Box score |