| Oct 8, 1948 | Alabama 48, Duquesne 6 | Box score |
| Oct 8, 1948 | Detroit Mercy 40, San Francisco 7 | Box score |
| Oct 8, 1948 | 10Penn State 34, Syracuse 14 | Box score |
| Oct 8, 1948 | Richmond 7, Furman 0 | Box score |
| Oct 8, 1948 | Villanova 19, Miami 10 | Box score |
| Oct 8, 1948 | Wichita State 21, Drake 20 | Box score |
| Oct 9, 1948 | Arizona 20, Hardin Simmons 14 | Box score |
| Oct 9, 1948 | 5Army 26, Illinois 21 | Box score |
| Oct 9, 1948 | Baylor 23, 13Arkansas 7upset | Box score |
| Oct 9, 1948 | Boston University 14, Colgate 13 | Box score |
| Oct 9, 1948 | 9California 40, Wisconsin 14 | Box score |
| Oct 9, 1948 | Clemson 21, Mississippi State 7upset | Box score |
| Oct 9, 1948 | Colorado 19, Nebraska 6 | Box score |
| Oct 9, 1948 | Colorado State 14, Denver 10 | Box score |
| Oct 9, 1948 | Columbia 34, Yale 28 | Box score |
| Oct 9, 1948 | Cornell 40, 18Harvard 6upset | Box score |
| Oct 9, 1948 | Dartmouth 19, Holy Cross 6 | Box score |
| Oct 9, 1948 | Duke 28, Navy 7 | Box score |
| Oct 9, 1948 | Florida 16, Auburn 9 | Box score |
| Oct 9, 1948 | George Washington 20, Virginia 12upset | Box score |
| Oct 9, 1948 | Georgia 35, Kentucky 12 | Box score |
| Oct 9, 1948 | 6Georgia Tech 27, Washington and Lee 0 | Box score |
| Oct 9, 1948 | Iowa 14, 11Ohio State 7upset | Box score |
| Oct 9, 1948 | Kansas 20, Iowa State 7 | Box score |
| Oct 9, 1948 | LSU 14, Texas A&M 13 | Box score |
| Oct 9, 1948 | Marquette 47, Saint Louis 7 | Box score |
| Oct 9, 1948 | Maryland 28, Virginia Tech 0 | Box score |
| Oct 9, 1948 | 7Michigan 40, 15Purdue 0 | Box score |
| Oct 9, 1948 | 13Ole Miss 20, Vanderbilt 7 | Box score |
| Oct 9, 1948 | Missouri 20, 4SMU 14upset | Box score |
| Oct 9, 1948 | New Mexico 61, New Mexico State 0 | Box score |
| Oct 9, 1948 | 2North Carolina 28, Wake Forest 6 | Box score |
| Oct 9, 1948 | NC State 40, Davidson 0 | Box score |
| Oct 9, 1948 | 3Northwestern 19, 8Minnesota 16 | Box score |
| Oct 9, 1948 | 1Notre Dame 26, Michigan State 7 | Box score |
| Oct 9, 1948 | Oklahoma 20, 16Texas 14upset | Box score |
| Oct 9, 1948 | Oregon 15, Idaho 8 | Box score |
| Oct 9, 1948 | 12Pennsylvania 29, Princeton 7 | Box score |
| Oct 9, 1948 | Pittsburgh 16, West Virginia 6 | Box score |
| Oct 9, 1948 | Rutgers 34, Temple 20 | Box score |
| Oct 9, 1948 | Santa Clara 27, Stanford 14 | Box score |
| Oct 9, 1948 | USC 7, Rice 0 | Box score |
| Oct 9, 1948 | 20Tennessee 26, Chattanooga 0 | Box score |
| Oct 9, 1948 | TCU 7, 17Indiana 6upset | Box score |
| Oct 9, 1948 | Texas Tech 41, Tulsa 20 | Box score |
| Oct 9, 1948 | UTEP 21, West Texas 7 | Box score |
| Oct 9, 1948 | Tulane 14, South Carolina 0 | Box score |
| Oct 9, 1948 | Utah 30, BYU 0 | Box score |
| Oct 9, 1948 | Utah State 22, Arizona State 17 | Box score |
| Oct 9, 1948 | Washington 27, UCLA 6 | Box score |
| Oct 9, 1948 | Washington State 48, Montana 0 | Box score |
| Oct 9, 1948 | William & Mary 31, VMI 0 | Box score |