| Sep 28, 1945 | Detroit Mercy 32, Alma 0 | Box score |
| Sep 28, 1945 | Maryland 60, Guilford 6 | Box score |
| Sep 28, 1945 | Maxwell Field 7, Auburn 0upset | Box score |
| Sep 28, 1945 | Saint Louis 96, Truman State 6 | Box score |
| Sep 29, 1945 | Alabama 21, Keesler Field 0 | Box score |
| Sep 29, 1945 | Army 32, Louisville Field 0 | Box score |
| Sep 29, 1945 | Boston College 13, Squantum NAS 0 | Box score |
| Sep 29, 1945 | Oregon State 14, Camp Beale 14 | Box score |
| Sep 29, 1945 | Scranton 0, Coast Guard 0 | Box score |
| Sep 29, 1945 | Colgate 48, Rochester (NY) 0 | Box score |
| Sep 29, 1945 | Colorado State 33, Northern Colorado 0 | Box score |
| Sep 29, 1945 | Columbia 40, Lafayette 14 | Box score |
| Sep 29, 1945 | Cornell 19, Bucknell 8 | Box score |
| Sep 29, 1945 | Corpus Christi NAS 22, SMU 7upset | Box score |
| Sep 29, 1945 | Drake 40, Kearney Field 13 | Box score |
| Sep 29, 1945 | Duke 76, Bogue Field 0 | Box score |
| Sep 29, 1945 | Iowa 14, Berg Field 13 | Box score |
| Sep 29, 1945 | Iowa State 48, Northern Iowa 13 | Box score |
| Sep 29, 1945 | Merchant Marine 26, Rensselaer 19 | Box score |
| Sep 29, 1945 | Miami 27, Chattanooga 7 | Box score |
| Sep 29, 1945 | Mississippi State 31, Louisiana 0 | Box score |
| Sep 29, 1945 | New Mexico 39, Lubbock Field 0 | Box score |
| Sep 29, 1945 | Penn State 47, Muhlenberg 7 | Box score |
| Sep 29, 1945 | South Carolina 40, Presbyterian 0 | Box score |
| Sep 29, 1945 | Texas 46, Southwestern U 0 | Box score |
| Sep 29, 1945 | UCLA 20, San Diego Navy 14 | Box score |
| Sep 29, 1945 | Utah State 45, Idaho Marines 0 | Box score |
| Sep 29, 1945 | Vanderbilt 12, Tennessee Tech 0 | Box score |
| Sep 29, 1945 | VMI 40, Richmond 6 | Box score |
| Sep 29, 1945 | Washington State 43, Idaho 12 | Box score |
| Sep 29, 1945 | William & Mary 19, Catawba 6 | Box score |
| Sep 29, 1945 | Yale 27, Tufts 7 | Box score |