| Oct 29, 1918 | Chicago 6, Loyola Academy 0 | Box score |
| Nov 2, 1918 | Arkansas 12, Missouri State 6 | Box score |
| Nov 2, 1918 | Camp Greenleaf 14, Sewanee 0upset | Box score |
| Nov 2, 1918 | Camp Taylor 7, Indiana 3upset | Box score |
| Nov 2, 1918 | Chicago Naval Reserve 25, Northwestern 0upset | Box score |
| Nov 2, 1918 | Colorado School of Mines 47, Camp Logan 9 | Box score |
| Nov 2, 1918 | Davidson 14, North Carolina 0 | Box score |
| Nov 2, 1918 | Fort Lewis 21, Oregon State 6upset | Box score |
| Nov 2, 1918 | Furman 20, 48th Infantry 7 | Box score |
| Nov 2, 1918 | Grinnell 71, Drake 0upset | Box score |
| Nov 2, 1918 | Kelly Field 28, Rice 0upset | Box score |
| Nov 2, 1918 | Lehigh 54, Muhlenberg 0 | Box score |
| Nov 2, 1918 | Mare Island Navy 80, Stanford 0upset | Box score |
| Nov 2, 1918 | Michigan State 16, Western Michigan 7 | Box score |
| Nov 2, 1918 | Navy 66, St. Helena NTS 0 | Box score |
| Nov 2, 1918 | NC State 54, Guilford 0 | Box score |
| Nov 2, 1918 | Notre Dame 67, Wabash 7 | Box score |
| Nov 2, 1918 | Oklahoma 58, Post Field 0 | Box score |
| Nov 2, 1918 | Oregon 41, Foundation 0 | Box score |
| Nov 2, 1918 | Payne Field 7, Mississippi State 6upset | Box score |
| Nov 2, 1918 | Rutgers 40, Hoboken Navy 0 | Box score |
| Nov 2, 1918 | SMU 6, Love Field 0 | Box score |
| Nov 2, 1918 | Southwestern U 65, Howard Payne 0 | Box score |
| Nov 2, 1918 | TCU 39, North Texas 0 | Box score |
| Nov 2, 1918 | Washington & Jefferson 68, Camp Sherman 0 | Box score |
| Nov 2, 1918 | Washington St. Louis 26, Missouri–Rolla 0 | Box score |
| Nov 2, 1918 | Wisconsin 21, Beloit 0 | Box score |
| Nov 2, 1918 | Penn State 6, Wissahickon Barracks 6 | Box score |
| Nov 3, 1918 | Auburn 20, Marion 7 | Box score |
| Nov 3, 1918 | Camp Devens 19, Brown 7upset | Box score |
| Nov 3, 1918 | Swarthmore 20, Pennsylvania 12upset | Box score |
| Nov 3, 1918 | Texas 26, Ream Field 2 | Box score |