1888: Week 3
Nine games. Winners are listed first; numbers before names are AP ranks going in.
FBS vs. FBS
| Oct 10, 1888 | Lafayette 54, Bucknell 0 | Box score |
| Oct 10, 1888 | Princeton 63, Pennsylvania 0 | Box score |
| Oct 13, 1888 | Yale 34, Pennsylvania 0 | Box score |
Everyone else
| Oct 10, 1888 | Harvard 30, Exeter 6 | Box score |
| Oct 10, 1888 | Trinity (CT) 0, Amherst 0 | Box score |
| Oct 13, 1888 | Harvard 34, Wesleyan (CT) 0 | Box score |
| Oct 13, 1888 | Lafayette 18, Swarthmore 0 | Box score |
| Oct 13, 1888 | Princeton 80, Stevens 0 | Box score |
| Oct 13, 1888 | Williams 53, Amherst 0 | Box score |