Running back, Louisville (from Wisconsin), 2018–⁠23

Isaac Guerendo

Number
No. 23
Height
6′1″
Weight
225 lb
Class (2023)
Senior
Hometown
Clayton, IN
Born
Jun 28, 2000

Isaac Guerendo played running back at Wisconsin (2018–⁠22) and Louisville (2023). The San Francisco 49ers took Guerendo in round 4, No. 129 overall in the 2024 NFL Draft.

At a glance

Best season
810
Rushing yards, 2023 (Louisville, 10–⁠4)
Drafted
No. 129
Round 4, 2024 NFL Draft (San Francisco 49ers)

Career highs

161rushing yards, career highvs. USC, 20233rushing touchdowns, career hightwice; last vs. USC, 2023

Rushing

Rushing yards, season by season, with his team’s record
SeasonTeamCarYdsAvgTDLong
2019Wisconsin111.001
2020Wisconsin11363.3013
2021Wisconsin231607.0182
2022Wisconsin653906.0589
2023Louisville1328106.11173
Career2321,3976.01789

Returns

SeasonTeamKRYdsTD
2019Wisconsin0490
2022Wisconsin204540
2023Louisville112110
Career317140

Receiving

SeasonTeamRecYdsAvgTDLong
2019Wisconsin133.003
2021Wisconsin263.006
2022Wisconsin171156.8127
2023Louisville2223410.6025
Career423588.5127

Defense

SeasonTeamTklSoloTFLSacksPDHur
2019Wisconsin110000
2020Wisconsin100000
2021Wisconsin110000
2022Wisconsin220000
Career540000

Season lines from CollegeFootballData, regular season and bowls.

On the roster

SeasonTeamNo.PosClassHtWt
2019Wisconsin23RBYr 1
2020Wisconsin23RBYr 2
2021Wisconsin23RBYr 3
2022Wisconsin23RBYr 4
2023Louisville23RBSr. (Yr 5)6′1″225

As each season’s roster listed the player (CollegeFootballData). Classes before the latest listing are counted back from it; “Yr 1” is the year on file where that count can’t place a season he played (a redshirt, transfer or 2020 year); height and weight as last listed.

Per play

SeasonTeamPlaysEPA/playPctileMedianTotalUsageAdj. rush
2019Wisconsin2-0.30––-0.6––
2020Wisconsin11-0.01––-0.1––
2021Wisconsin220.16––3.58%–
2022Wisconsin870.1654th (n=470)0.1413.712%0.26
2023Louisville1560.3083rd (n=450)0.1746.317%0.30

Expected points added: how much the player’s plays moved the team’s expected score, per play and in total. Plays: total EPA divided by EPA per play, the plays the source credits to him (for a receiver roughly his catches and runs, not every target; for a passer, not every attempt), so it can differ from attempts plus carries. Percentile: against the position’s regulars that season across all divisions on file (quarterbacks with 150+ plays, backs 60+, receivers and tight ends 30+), with how many there were (n) and their median; a dash means too few plays to rank. A season in progress uses the full-season bar scaled by games played, never below 75 plays for quarterbacks, 30 for backs and 20 for receivers. The cohort grows or shrinks with the source’s coverage each season (2025 lists far more players), so compare percentiles rather than raw EPA across years. FCS seasons are marked. Usage: the share of the team’s plays the player was part of (shown from 20 plays). Adjusted pass and rush: EPA per play adjusted for the defenses faced (CollegeFootballData’s WEPA). From CollegeFootballData, 2013 on.

Game by game

2023 Louisville 14 games, 810 rushing yards, 11 TD
DateOpponentResultCarRush ydsRush TDKRYds
Sep 1vs.Georgia TechW 39–⁠346270––
Sep 7vs.Murray StateW 56–⁠011631––
Sep 16vs.IndianaW 21–⁠145160––
Sep 23vs.Boston CollegeW 56–⁠28936029
Sep 29atNC StateW 13–⁠10–––––
Oct 7vs.Notre DameW 33–⁠208270––
Oct 14atPittsburghL 21–⁠381338217
Oct 28vs.DukeW 23–⁠08450––
Nov 4vs.Virginia TechW 34–⁠3111463––
Nov 9vs.VirginiaW 31–⁠246941237
Nov 18atMiamiW 38–⁠3115931120
Nov 25vs.KentuckyL 31–⁠3813540284
Dec 2vs.Florida StateL 6–⁠164100116
Dec 27 ✦vs.USCL 28–⁠42231613238
2022 Wisconsin 12 games, 390 rushing yards, 5 TD
DateOpponentResultCarRush ydsRush TDKRYds
Sep 3vs.Illinois StateW 38–⁠0231133
Sep 10vs.Washington StateL 14–⁠173140119
Sep 17vs.New Mexico StateW 66–⁠712742150
Sep 24atOhio StateL 21–⁠522−50382
Oct 1vs.IllinoisL 10–⁠341305107
Oct 8atNorthwesternW 42–⁠7130224
Oct 15atMichigan StateL 28–⁠34220256
Oct 22vs.PurdueW 35–⁠247721––
Nov 5vs.MarylandW 23–⁠10121141132
Nov 12atIowaL 10–⁠247280451
Nov 19atNebraskaW 15–⁠149420––
Nov 26vs.MinnesotaL 16–⁠237400––
2021 Wisconsin 4 games, 160 rushing yards, 1 TD
DateOpponentResultCarRush ydsRush TDKRYds
Sep 4vs.Penn StateL 10–⁠1613560––
Sep 11vs.Eastern MichiganW 34–⁠74921––
Sep 25vs.Notre DameL 13–⁠41450––
Oct 2vs.MichiganL 17–⁠38270––
2020 Wisconsin 2 games, 36 rushing yards
DateOpponentResultCarRush ydsRush TDKRYds
Oct 23vs.IllinoisW 45–⁠711360––
Nov 21atNorthwesternL 7–⁠17–––––
2019 Wisconsin 2 games, 1 rushing yard
DateOpponentResultCarRush ydsRush TDKRYds
Nov 30atMinnesotaW 38–⁠17–––049
Jan 1 ✦vs.OregonL 27–⁠28110––

Box scores from CollegeFootballData, 2004 on. ✦ postseason; ★ a career high on file.

Before the draft

DrillCombine 2024Combine or pro day 2024
Height6′0″
Weight221 lb
Arm length30¾″
Hand size9¼″
Wingspan74⅞″W
40-yard dash4.33 s
10-yard split1.55 s
Vertical jump41½″
Broad jump10′9″
Bench press17 reps
3-cone drill6.94 s
20-yard shuttle4.15 s

Combine or pro day: the source doesn’t say which. Unmarked: Combine and pro day results compiled by array-carpenter (nfl-draft-data); W: Pre-draft measurables: Wikipedia (CC BY-SA).

In the NFL

2 seasons, 23 games with a stat; latest team: San Francisco 49ers.

SeasonTeamGCarYdsTDRecRec yds
2024San Francisco 49ers1684420415152
2025San Francisco 49ers700000
NFL career2384420415152

Regular seasons, from nflverse (CC BY 4.0). G counts games in which the player recorded a stat.

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